Lars Hannibal began playing the guitar at the age of 15 as many others of his generation. Some years later, a recording by Andrès Segovia, playing the Gavotte from Bach`s E-Major Partita, impressed him so much, that he decided to start playing the Classical guitar. He studied at the music Conservatory in Århus with Erling Møldrup, and from 1977-80 the lute with Toyohiko Satoh in The Hague. In 1980 Lars Hannibal formed Duo Concertante with violinist Kim Sjøgren, together they toured 15 years in Denmark, Germany, France, Spain and UK, giving more than a thousand concerts. As something new at the time they developed a concert form, where information, anecdotes and humor were an integrated part, easening up the concert form at the time. Many established Danish composers wrote works for Duo Concertante during this period. For EMI they recorded 10 albums with a repertoire ranging from the contemporary works composed for the Duo over famous classics (Paganini, Sarasate) to cross-over projects with artists from other genres. The openness towards genres was also influential in Duo Concertantes forming Birth of a Quartet in 1988 together with trumpet player and composer Palle Mikkeborg and Double bass Player Niels Henning Ørsted Pedersen. Duo Concertante also toured and recorded with Danish Pop singer Birthe Kjær and Jazz violinist Svend Asmussen.
In 2004 Lars Hannibal started a project with Chinese Musicians in various formations, under the mutual name: Dialogue - East meets West. As part of this he was appointed curator for the Danish EXPO Participation in Shanghai 2010, where he brought Danish and Chinese artists together with Shanghai Symphony Orchestra in a large show often shown at CCTV.
Further collaborations have included performances with Danish Actress Ghita Nørby in a performance having words and music in dialogue, taking up subjects of the present day.